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SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7
USERS' SCORE
Good
Based on 12 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
9
Cod liver oil and heart health
Fish oil, atherogenesis, and thrombogenesis.
Strong relevance to cardiovascular effects
We examined how cod liver oil might influence cardiovascular disease, particularly in relation to atherogenesis and thrombogenesis. Previous observations suggested that eating marine fish can lower the risk of ischemic heart disease. However, the universal recommendation for fish oil as a supplement remains uncertain due to potential side effects associated with high dosages.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Read More
9
Cod liver oil aids diabetic heart health
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats.
Direct effect of CLO on diabetes
We explored the effects of cod liver oil (CLO) on cardiovascular health in rats with diabetes, particularly how it might improve various related issues. In our study, diabetic rats were treated with CLO for 12 weeks and we compared their health with untreated diabetic rats.
Results showed that CLO treatment led to notable improvements. It helped prevent weight loss and completely corrected the abnormal lipid levels found in these diabetic rats. While it didn't fully normalize blood sugar levels, it did help control them partially, which is a positive step.
We also examined how CLO impacted the heart and blood vessels. The oil improved the functioning of blood vessels, alleviating some of the vasoconstriction caused by diabetes and restoring endothelial function. Moreover, CLO helped normalize heart contractions and responses to certain stimuli, suggesting better heart health.
Overall, we found that cod liver oil supplementation effectively targets cardiovascular issues linked to diabetes in these experimental models, making it a promising area for future research.
Results showed that CLO treatment led to notable improvements. It helped prevent weight loss and completely corrected the abnormal lipid levels found in these diabetic rats. While it didn't fully normalize blood sugar levels, it did help control them partially, which is a positive step.
We also examined how CLO impacted the heart and blood vessels. The oil improved the functioning of blood vessels, alleviating some of the vasoconstriction caused by diabetes and restoring endothelial function. Moreover, CLO helped normalize heart contractions and responses to certain stimuli, suggesting better heart health.
Overall, we found that cod liver oil supplementation effectively targets cardiovascular issues linked to diabetes in these experimental models, making it a promising area for future research.
Read More
8
Vitamin D improves heart disease factors
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Direct relevance to cardiovascular health
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Read More
Most Useful Reviews
9.5
Relieves headaches
Omega 3 is essential for cardiovascular and nervous systems. Following Irina’s recommendation, I experienced significant benefits. My headaches and joint crunch have disappeared. I'm excited to continue using it!
Read More
9.5
Improves anxiety
After using NOW Foods Cod Liver Oil, my overall health improved remarkably. It reduced inflammation, particularly for my joints related to arthritis, and even decreased my anxiety and depression. The softgels are easy to swallow, and I appreciate the quality and packaging, which reflect its value for supporting cardiovascular disease.
Read More
8.3
Non-GMO source
NOW Cod Liver Oil is rich in Omega-3 fatty acids and serves as an excellent source of Vitamins A and D3. With strict quality control, it effectively aids overall health and supports cardiovascular disease prevention.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7
9
DHA supports heart recovery post-MI
Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway.
Focus on DHA, not cod liver oil
We explored the effects of docosahexaenoic acid (DHA), a fatty acid found in cod liver oil, on heart health after a heart attack, known as myocardial infarction (MI). Using both lab-grown heart cells and mouse models, we investigated how DHA might protect against heart damage following an MI.
Our findings revealed that DHA significantly improved the survival of heart cells under stress and reduced damage in mouse hearts after MI. It not only decreased the size of heart tissue damage but also enhanced overall heart function and lowered fibrosis, which is the scarring of heart tissue.
In addition to these protective effects, we observed that DHA boosted autophagy, a process that helps cells clear out damaged components, and reduced cell death. We further noted that DHA promotes this beneficial process through the activation of the AMPK/mTOR signaling pathway, which is crucial for regulating cell energy and growth.
This study highlights the powerful cardiovascular benefits of DHA, suggesting that it could be a valuable component of heart health, particularly in supporting recovery after heart attacks.
Our findings revealed that DHA significantly improved the survival of heart cells under stress and reduced damage in mouse hearts after MI. It not only decreased the size of heart tissue damage but also enhanced overall heart function and lowered fibrosis, which is the scarring of heart tissue.
In addition to these protective effects, we observed that DHA boosted autophagy, a process that helps cells clear out damaged components, and reduced cell death. We further noted that DHA promotes this beneficial process through the activation of the AMPK/mTOR signaling pathway, which is crucial for regulating cell energy and growth.
This study highlights the powerful cardiovascular benefits of DHA, suggesting that it could be a valuable component of heart health, particularly in supporting recovery after heart attacks.
Read More
9
Cod liver oil aids diabetic heart health
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats.
Direct effect of CLO on diabetes
We explored the effects of cod liver oil (CLO) on cardiovascular health in rats with diabetes, particularly how it might improve various related issues. In our study, diabetic rats were treated with CLO for 12 weeks and we compared their health with untreated diabetic rats.
Results showed that CLO treatment led to notable improvements. It helped prevent weight loss and completely corrected the abnormal lipid levels found in these diabetic rats. While it didn't fully normalize blood sugar levels, it did help control them partially, which is a positive step.
We also examined how CLO impacted the heart and blood vessels. The oil improved the functioning of blood vessels, alleviating some of the vasoconstriction caused by diabetes and restoring endothelial function. Moreover, CLO helped normalize heart contractions and responses to certain stimuli, suggesting better heart health.
Overall, we found that cod liver oil supplementation effectively targets cardiovascular issues linked to diabetes in these experimental models, making it a promising area for future research.
Results showed that CLO treatment led to notable improvements. It helped prevent weight loss and completely corrected the abnormal lipid levels found in these diabetic rats. While it didn't fully normalize blood sugar levels, it did help control them partially, which is a positive step.
We also examined how CLO impacted the heart and blood vessels. The oil improved the functioning of blood vessels, alleviating some of the vasoconstriction caused by diabetes and restoring endothelial function. Moreover, CLO helped normalize heart contractions and responses to certain stimuli, suggesting better heart health.
Overall, we found that cod liver oil supplementation effectively targets cardiovascular issues linked to diabetes in these experimental models, making it a promising area for future research.
Read More
9
Cod liver oil and heart health
Fish oil, atherogenesis, and thrombogenesis.
Strong relevance to cardiovascular effects
We examined how cod liver oil might influence cardiovascular disease, particularly in relation to atherogenesis and thrombogenesis. Previous observations suggested that eating marine fish can lower the risk of ischemic heart disease. However, the universal recommendation for fish oil as a supplement remains uncertain due to potential side effects associated with high dosages.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Our research revealed that while fish oil lowers cholesterol and triglyceride levels, it can also increase levels of low-density lipoprotein, which raises concerns about free radical generation and bleeding. Interestingly, moderate intake of marine fish has shown protective effects against heart disease without significantly changing traditional measurements like cholesterol levels or blood clotting times.
In a controlled study with swine, we noted that adding cod liver oil to a high-fat diet resulted in fewer monocyte adhesions and platelet clumps in critical heart arteries, suggesting that it plays a role in reducing clotting risks. To delve deeper into the mechanisms, we conducted an in vitro experiment where we treated endothelial cells with varying fatty acids.
Among these, only eicosapentaenoic acid (EPA) stood out in diminishing the binding of human monocytes to the endothelial cells, especially when applied within a specific timeframe after stimulation. Moreover, we found that EPA decreased the expression of certain adhesion molecules on endothelial cells following inflammatory stimulation.
Overall, our findings suggest that cod liver oil could be a potentially valuable addition to heart health strategies, particularly due to its unique ability to influence blood vessel interactions without significant adverse effects.
Read More
8
Vitamin D improves heart disease factors
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Direct relevance to cardiovascular health
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Read More
8
Cod liver oil may reduce CHD risk
Longitudinal associations between marine omega-3 supplement users and coronary heart disease in a UK population-based cohort.
Directly addresses health implications
We conducted a comprehensive analysis to understand how marine omega-3 supplements, especially cod liver oil, influence the risk of coronary heart disease (CHD). Our study was based on a large group of 22,035 men and women from the Norfolk area, tracked over a median period of 19 years. Participants were categorized based on their supplement use into three groups: those who did not use supplements, those who used omega-3 supplements, and those who used other types of supplements.
Throughout the study, we discovered that recent users of omega-3 supplements had a noticeably lower risk of CHD mortality compared to non-supplement users. It is important to note that while we observed these promising results, there could be other factors at play that might influence the outcomes. Nevertheless, the association between taking omega-3 supplements and a reduced risk for heart disease is intriguing, especially considering our participants generally had low fish consumption.
In conclusion, while our findings suggest that cod liver oil might be associated with heart health benefits, further research is needed to understand the full implications and mechanism behind these results. This is an encouraging area of study for those looking to improve cardiovascular health through dietary choices.
Throughout the study, we discovered that recent users of omega-3 supplements had a noticeably lower risk of CHD mortality compared to non-supplement users. It is important to note that while we observed these promising results, there could be other factors at play that might influence the outcomes. Nevertheless, the association between taking omega-3 supplements and a reduced risk for heart disease is intriguing, especially considering our participants generally had low fish consumption.
In conclusion, while our findings suggest that cod liver oil might be associated with heart health benefits, further research is needed to understand the full implications and mechanism behind these results. This is an encouraging area of study for those looking to improve cardiovascular health through dietary choices.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.6
9.5
Supports cardiovascular health
Cod liver oil is crucial for skin clarity, heart health, memory, and immunity against infections. It reduces cholesterol and triglycerides. Unlike other fish oils, it comes from cod liver, containing more Vitamins A and D, crucial for preventing cardiovascular disease.
9.5
Relieves headaches
Omega 3 is essential for cardiovascular and nervous systems. Following Irina’s recommendation, I experienced significant benefits. My headaches and joint crunch have disappeared. I'm excited to continue using it!
9.5
Improves anxiety
After using NOW Foods Cod Liver Oil, my overall health improved remarkably. It reduced inflammation, particularly for my joints related to arthritis, and even decreased my anxiety and depression. The softgels are easy to swallow, and I appreciate the quality and packaging, which reflect its value for supporting cardiovascular disease.
Read More
8.8
Supports heart health
Cod liver oil has multiple benefits for overall health. It reduces inflammation, eases arthritis pain, alleviates anxiety and depression, lowers diabetes risk, and supports the immune system. It's an excellent source of Vitamins A and D3, providing significant support for cardiovascular disease.
Read More
8.8
Improves joint pain
I recommend fish oil for my sister's joint problems. May God heal her. It's vital for reducing inflammation and supporting heart health. She feels the difference and keeps repurchasing due to its positive impact on her condition.
